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Across 114 countries, antibiotic use tracked resistance in some pathogen–drug pairs; a modeled 10% reduction was associated with 38,000 fewer annual AMR deaths, a modest share of bacterial mortality.
A PLOS Biology article argues that Alzheimer’s vascular research must connect molecular changes in brain vessels to mechanics, blood flow and tissue perfusion before treating them as causes of disease.
A Welsh record-linkage study finds that income deprivation tracked GCSE attainment more strongly than major congenital anomalies; accounting for special education provision narrowed some gaps, but causes remain uncertain.
A simulation study suggests natural Shigella exposure could make vaccine efficacy look lower in high-burden trials, but the size of that bias depends on uncertain assumptions about immunity.